Joslin Receives $24.3 Million Grant from the NIH for Diabetic Kidney Disease Study

Joslin Receives $24.3 Million Grant from the NIH for Diabetic Kidney Disease Study


people with diabetes are at great risk for end-stage renal
disease. A new research project at Joslin Diabetes Center funded by a $25 million dollar NIH grant
will look for new ways to prevent this Dr. Doria: the aim is to see whether by decreasing uric acid in people who are at risk of kidney complications really
can slow down or even halt their progression to chronic kidney
disease and to end stage renal disease.
Narration: this 8 Center clinical study
will be led by joslin’s doctor Alessandro Doria and the University of Minnesota’s doctor
michael Mauer other sites include Colorado Michigan
Chicago New York Toronto Canada and Copenhagen
Denmark Doria: the group is actually called PERL, which is Preventing Early Renal Loss in Diabetes. The current estimates suggest that about 10 to 15 percent of people with diabetes develop end stage renal disease meaning
that they need either a renal transplant or
they need hemodialysis to survive we need additionally intervention that
acts together with good glycemic control, trying
to cub diabetic complications.
Narration: The three-year
trial of approximately 500 people will test if a generic drug called allopurinol will reduce the occurrence
of kidney disease in people with type 1 diabetes allopurinol has already been shown to
reduce uric acid levels and has been on the market since the
1930s as a treatment for gout Doria: we performed a fairly large study here
at the Joslin this was done together with
Andrzej Krolewski in the same section where I work and basically what we did was to follow
a group of people with type 1 diabetes for several years and what
we saw was that the levels of uric acid at the beginning of this study were
predictive of how quickly somebody would lose kidney function now this an association; we don’t know
whether there is a causal link but that’s why we
are doing this study to try to see whether by
decreasing uric acid actually we can slow down this decline kidney function
hopefully if this is a positive, if we have positive findings we’ll have a new intervention, so we’d have a new
therapy for a kidney complications. But also by trying to understand the mechanisms through which this happens might give us other targets that we could act upon

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