Researchers reveal fail safe structure of enzyme linked to Alzheimer’s

Researchers reveal fail safe structure of enzyme linked to Alzheimer’s


So what I was able to do is solve the
atomic structure of ATOM10. ATOM10 enables cells a pathway which they
can communicate with their extracellular environment and this is important in
embryonic development, as well as maintaining tissue homeostasis later
through adulthood. Dysfunction in ATOM10 activity is implicated in a
wide variety of pathologies such as Alzheimer’s disease, cancer progression
and asthma. What this structure gives is it gives researchers
a road map in which they can then better understand how this protein is
working. So what we can see here in the structure is we have the business-end,
or the purple domain, which actually does all the the cutting of proteins on
the cell surface followed by this blue and green domains which are these
regulatory domains and that they wrap actually around the purple domain and
capture it in this off state. So what we’re showing for the first time is the
protein seems to be self-regulating to a degree and this all states important and
that it keeps the protein from continuously cutting on the cell surface
and that there must be an on state in which the regulatory domain releases the
other domain and allows it to then go about cutting proteins on the cell
surface. My hope is with the structure that this
roadmap should inform scientists as to how to now design therapies or potential
therapeutics for this protein specifically
and potentially maybe help move us a little bit closer to helping patients
that are suffering from neurologic dysfunction as well as as cancers that
this protein is involved in.

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